Reference 1: Brown MG, Sillau S, McDermott D, Ernst LD, Spencer DC, Englot DJ, González HFJ, Datta P, Karakis I, Becker D, Rolston JD, Arain A, Rao VR, Doherty M, Urban A, Drees C. Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy. Epilepsy Behav. 2022 Apr;129:108653. doi: 10.1016/j.yebeh.2022.108653. Epub 2022 Mar 16. PMID: 35305525.
Drees C, McDermott D, Sillau S, Abosch A, Ojemann S, Schwarz S, Brown MG. Seizure outcome with responsive neurostimulation (RNS) comparing strip versus depth leads. Epilepsy Behav. 2020 Nov;112:107402. doi: 10.1016/j.yebeh.2020.107402. Epub 2020 Sep 7. PMID: 32911300.
Geller EB. Responsive neurostimulation: Review of clinical trials and insights into focal epilepsy. Epilepsy Behav. 2018 Nov;88S:11-20. doi: 10.1016/j.yebeh.2018.06.042. Epub 2018 Sep 20. PMID: 30243756
Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia. 2017 Jun;58(6):994-1004. doi: 10.1111/epi.13740. Epub 2017 Apr 11. PMID: 28398014.
Hegde M, Chiong W, Rao VR. New Ethical and Clinical Challenges in "Closed-Loop" Neuromodulation. Neurology. 2021 Apr 27;96(17):799-804. doi: 10.1212/WNL.0000000000011834. Epub 2021 Mar 16. PMID: 33727407; PMCID: PMC8166428.
Hixon AM, Brown MG, McDermott D, Destefano S, Abosch A, Kahn L, Ojemann S, Drees C. RNS modifications to eliminate stimulation-triggered signs or symptoms (STS): Case series and practical guide. Epilepsy Behav. 2020 Nov;112:107327. doi: 10.1016/j.yebeh.2020.107327. Epub 2020 Jul 24. PMID: 32717707; PMCID: PMC7658023.
Inaji M, Yamamoto T, Kawai K, Maehara T, Doyle WK. Responsive Neurostimulation as a Novel Palliative Option in Epilepsy Surgery. Neurol Med Chir (Tokyo). 2021 Jan 15;61(1):1-11. doi: 10.2176/nmc.st.2020-0172. Epub 2020 Dec 2. PMID: 33268657; PMCID: PMC7812309.
Jarosiewicz B, Morrell M. The RNS System: brain-responsive neurostimulation for the treatment of epilepsy. Expert Rev Med Devices. 2021 Feb;18(2):129-138. doi: 10.1080/17434440.2019.1683445. Epub 2020 Sep 16. PMID: 32936673.
Khan M, Paktiawal J, Piper RJ, Chari A, Tisdall MM. Intracranial neuromodulation with deep brain stimulation and responsive neurostimulation in children with drug-resistant epilepsy: a systematic review. J Neurosurg Pediatr. 2021 Oct 22:1-10. doi: 10.3171/2021.8.PEDS21201. Epub ahead of print. PMID: 34678764.
Khankhanian P, Lee AM, Drees CN, Decker BM, Becker DA. Combined VNS-RNS Neuromodulation for Epilepsy. J Clin Neurophysiol. 2022 Feb 1;39(2):e5-e9. doi: 10.1097/WNP.0000000000000870. PMID: 35130199; PMCID: PMC8822089.
Kwon CS, Ripa V, Al-Awar O, Panov F, Ghatan S, Jetté N. Epilepsy and Neuromodulation-Randomized Controlled Trials. Brain Sci. 2018 Apr 18;8(4):69. doi: 10.3390/brainsci8040069. PMID: 29670050; PMCID: PMC5924405.
Reference 2: Ma BB, Rao VR. Responsive neurostimulation: Candidates and considerations. Epilepsy Behav. 2018 Nov;88:388-395. doi: 10.1016/j.yebeh.2018.09.032. Epub 2018 Oct 22. PMID: 30355456.
Matias CM, Sharan A, Wu C. Responsive Neurostimulation for the Treatment of Epilepsy. Neurosurg Clin N Am. 2019 Apr;30(2):231-242. doi: 10.1016/j.nec.2018.12.006. Epub 2019 Feb 18. PMID: 30898274.
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE Jr, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ; RNS System LTT Study. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20. PMID: 32690786; PMCID: PMC7538230.
Nagahama Y, Zervos TM, Murata KK, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips HW, Fajardo M, Nariai H, Hussain SA, Porter BE, Grant GA, Ragheb J, Wang S, O'Neill BR, Alexander AL, Bollo RJ, Fallah A. Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study. Neurosurgery. 2021 Nov 18;89(6):997-1004. doi: 10.1093/neuros/nyab343. PMID: 34528103; PMCID: PMC8637802.
Nune G, Arcot Desai S, Razavi B, Agostini MA, Bergey GK, Herekar AA, Hirsch LJ, Lee RW, Rutecki PA, Srinivasan S, Van Ness PC, Tcheng TK, Morrell MJ. Treatment of drug-resistant epilepsy in patients with periventricular nodular heterotopia using RNS® System: Efficacy and description of chronic electrophysiological recordings. Clin Neurophysiol. 2019 Aug;130(8):1196-1207. doi: 10.1016/j.clinph.2019.04.706. Epub 2019 May 9. PMID: 31163364.
Reference 3: Skarpaas TL, Jarosiewicz B, Morrell MJ. Brain-responsive neurostimulation for epilepsy (RNS® System). Epilepsy Res. 2019 Jul;153:68-70. doi: 10.1016/j.eplepsyres.2019.02.003. Epub 2019 Feb 20. PMID: 30850259.
Starnes K, Miller K, Wong-Kisiel L, Lundstrom BN. A Review of Neurostimulation for Epilepsy in Pediatrics. Brain Sci. 2019 Oct 18;9(10):283. doi: 10.3390/brainsci9100283. PMID: 31635298; PMCID: PMC6826633.
Welch WP, Hect JL, Abel TJ. Case Report: Responsive Neurostimulation of the Centromedian Thalamic Nucleus for the Detection and Treatment of Seizures in Pediatric Primary Generalized Epilepsy. Front Neurol. 2021 Apr 28;12:656585. doi: 10.3389/fneur.2021.656585. PMID: 33995254; PMCID: PMC8113700.
Youngerman BE, Mahajan UV, Dyster TG, Srinivasan S, Halpern CH, McKhann GM, Sheth SA. Cost-effectiveness analysis of responsive neurostimulation for drug-resistant focal onset epilepsy. Epilepsia. 2021 Nov;62(11):2804-2813. doi: 10.1111/epi.17049. Epub 2021 Aug 29. PMID: 34458986.
Zawar I, Krishnan B, Mackow M, Alexopoulos A, Nair D, Punia V. The Efficacy, Safety, and Outcomes of Brain-responsive Neurostimulation (RNS® System) therapy in older adults. Epilepsia Open. 2021 Dec;6(4):781-787. doi: 10.1002/epi4.12541. Epub 2021 Oct 4. PMID: 34543516; PMCID: PMC8633477.