ARUBA – lessons learned from a controversial trial

Reference 1:
Mohr, J P, Prof, Parides, Michael K, Prof, Stapf, Christian, Prof, Moquete, Ellen, RN, Moy, Claudia S, PhD, Overbey, Jessica R, MS, Salman, Rustam Al-Shahi, Prof, Vicaut, Eric, Prof, Young, William L, Prof, Houdart, Emmanuel, Prof, Cordonnier, Charlotte, Prof, Stefani, Marco A, Prof, Hartmann, Andreas, MD, von Kummer, Rüdiger, Prof, Biondi, Alessandra, Prof, Berkefeld, Joachim, Prof, Klijn, Catharina J M, MD, Harkness, Kirsty, MD, Libman, Richard, MD, … Moskowitz, Alan J, Prof. (2014). Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. The Lancet (British Edition), 383(9917), 614–621. https://doi.org/10.1016/S0140-6736(13)62302-8

Reference 2:
Lang, Moore, N. Z., Rasmussen, P. A., & Bain, M. D. (2018). Treatment Outcomes of A Randomized Trial of Unruptured Brain Arteriovenous Malformation-Eligible Unruptured Brain Arteriovenous Malformation Patients. Neurosurgery, 83(3), 548–555. https://doi.org/10.1093/neuros/nyx506

Reference 3:
Pulli, Chapman, P. H., Ogilvy, C. S., Patel, A. B., Stapleton, C. J., Leslie-Mazwi, T. M., Hirsch, J. A., Carter, B. S., & Rabinov, J. D. (2020). Multimodal cerebral arteriovenous malformation treatment: a 12-year experience and comparison of key outcomes to ARUBA. Journal of Neurosurgery, 133(6), 1792–1801. https://doi.org/10.3171/2019.8.JNS19998